Digitization is the key for future manufacturing! Europe needs to speed up with respect to the digital transformation of its industry in order to maintain its competitiveness. Instead of single manufacturing sites, integrated manufacturing eco-systems needs to come up with customer satisfaction and environmentally friendly production as the leading principles. The joint Cross-KIC project will give a valuable contribution to the European manufacturing eco-systems by establishing, in selected Co-Location Centers, innovative and future proof end-to-end digitized test beds considering the whole product life cycle. This drives the digitization of manufacturing by leveraging digital technologies such as AI and 5G. EIT Manufacturing, EIT Digital and EIT Food will jointly demonstrate the benefits of digital transformation across sectors. Together, we will be able to highlight the benefits of digitalization and attract a large number of SMEs to adopting digital manufacturing solutions.